EVELOPMENT OF A NON-BLEEDING CARDIO-VASCULAR WALL SUBSTITUTE UNDER FIBRINOLYSIS PHENOMENON

Abstract

A cardiovascular wall substitute which did not show any bleeding through the wall under fibrinolysis condition was developed. A piece of adipose connective tissue was minced with scissors and then stirred into saline to create a tissue suspension. This suspension was enmeshed into the wall of a highly porous fabric vascular prosthesis by repeated pressurized injections using a syrings. A non-meshed area of the same prosthesis was preclotted and used as the control. Tissue plasminogen activator was injected intravenously 1 hour after complete stop bleeding from the graft area. However, no bleeding at area of the tissue fragments enmeshing. This method enable to easily produce the graft with any size and shape in the surgery room. Such a graft is expected to have a high healing ability of the neointima of the graft surface.