Abstract
We studied the effect of the high porous vascular graft (porosity 2000-3200ml/cm2/min, 3mm I.D. 3cm in length and 4-5mm I.D. 7-8cm in length) coated with plasmin treated fibrin (PF) on healing and patency by implanting in the abdominal aorta of rabbits and carotid artery of dogs. The graft coated with PF matrix showed good handling and non oozing. We recognized the excellent healing of PF-coated prosthesis which were covered with intima without hyperplasia and stenosis in the rabbits. In addition, in the dogs, good patency were observed on the PF coated graft. These results suggest that it is possible to develope the high porous vascular prosthesis which will ensure non oozing and antithrombogenicity and histocompatibility.
