Abstract
Drug intoxication cases in the Dialysis Unit, Tokai University School of Medicine, were collected during a ten year period from 1981 to 1990, and therapeutic usefulness of blood purification for drug intoxication was investigated in 82 cases. Furthermore in five dialysis patients with malignancy treated with CDDP and one case of malignantmelanoma treated with high-dose melphelan blood purification was conducted and its clinical effects were investigated
1) Blood purification for acute drug intoxication cases was effective measures for improvement of vital signs including conciousness, respiration and blood pressure.
2) Direct hemoperfusion using activated charcoal (DHP) for acute pesticide intoxication cases was effective for reducing plasma pesticide level and for improvement of vital signs.
3) Continuous intestinal irrigation using golytely, kayexalate and Magcorol, and continuous blood purification including plasma exchange (PE), followed by continuous DHP for paraquat intoxication improved survival.
4) Blood purification for cases with anticancer agents was effective for protection of side effects of the drugs.
