EFFECT OF LEFT VENTRICULAR ASSISTANCE ON THE INDUCED STUNNED MYOCARDIUM

Abstract

In order to evaluate the effect of left ventricular assistance on cardiac dysfunction due to the induced stunned myocardium after the reperfusion, acute experiments using adult goats was performed. After the implantation of our TH-7B pneumatically driven VAD as left heart bypass, left anterior discending artery (LAD) was reperfused after short time occulusion to constitute the model of the stunned myocardium. Pressure-Volume curve (P-V curve) and E_max of left ventricle were obtained by our newly developed automatic hemodynamics analysing system to evaluate the recovery time from the transient left ventricular dysfunction. The recovery time were significantly decreased by the use of VAD. These results suggest that VAD is useful also for the transient ischemia to avoid to have heart muscle destroyed.