Abstract
We conducted and examined two experimental studies about eicosapentaenoic acid ethyl emulsion(EPA-E) in order to reduce the destruction of blood cells. We used the closed circuit(1), and the left heart bypass by centrifugal pump in mongrel dogs (2). Both studies, the main groups, we devided into two groups. One group was administrated EPA-E before examination (”EPA-E group”). Another group was not done (”control group”). We show the results as follows: 1.) In the closed circuit experiments, there was no significant difference between EPA-E group and control group. 2.) When EPA-E was administrated in left heart bypass in dogs, the level of erythro-aggregation was significantly lower, the increase of plasma free hemoglobin and decrease of platlet count were suppressed compared with control group. In addition, during aortic clamp, the reduction of urine output in EPA-E group was less than control group. And the recovery of urine output after aortic declamp was more quickly in EPA-E group.
