Abstract
The modifiedd cellulose was developed by fixing the modification agent to inner surface of regenerated cellulose hollow fiber during spinnig process. The modification agent (fluorine polymer) was fixed on the cellulose surface by covalent bonding, and antioxidantα-tocopherol (vitamin E) was fixed by hydrophobic bonding. ESCA showed that 39.9% fluorine atomic number rate was fixed on the inner surface of regenerated cellulose. Biocompatibility of modified cellulose membrane was tested compared to the original cellulose membrane by in vitro and extracorporeal circulation in mongrel dog. The modified cellulose showed excellent antithrombogenesis, and little complement activation hemodialysis leukopenia.
