Abstract
Adequate frequency of dialysate ex-change on APD was assessed by the kine-tic model for urea removal capacity. Maximum volume of dialysate infusion(MV)and in-traperitoneal pressure(IPP) were also studied in 7 adult and 4 pediatric patients. Maximum infusion volume on APDwas 2800 ml in patients with body weightof >60 kg, 2500 ml in patients of 50-60 Kg, 2100 ml in patients of 40-50 kg and 60 ml/kg in pediatric patients. An increment in IPP associated With increased dwelling volume was significantly lower in supine position than in upright and sitting position. Adequate frequency of exchange depended on the dwelling volume and peritoneal solute permeability, which was 5-6 times for patients with urea D/P(2 hrs) of 0.6 and 6-8 times for patients of 0.9. In conclusion, dwelling volume of 2000-2800 ml and frequency of exchange of 5-8 times seems to be adequate for adult patients on APD, which depended on the body fluid volume and peritoneal permeabi-lity.
