Abstract
An advent of a high performance dialyzer, which can effectively remove β2-microglobulin related to dialysis amyloidosis, brings a new issue in contamination of endotoxin through the membrane by back filtration and necessitates more sterile dialysate. We developed a new central dialysate delivery machine exclusively designed for glucose-added bicarbonate-buffered dry chemical (AKDD: Towa Pharm.) and evaluated it clinically for 2 weeks. The machine, which was operated for the total period of 216 hrs, produced amounts of dialysate as required at any time. The mean dialysate concentration during the whole period was Na 141±1.5 mEq/l, K 1.97±0.04 mEq/l, HC03-23.9±1.04mEq/l, Ca 2.70±0.03mEq/l, and Mg 1.10±0.01mEq/l. Dialysate endotoxin level varied from 0.74±1.01 pg/ml, at the start of operation to 1.41±2.01pg/ml(n=11) 6 hrs later. These results suggested that the machine can produce a dialysate with more consistent concentration and higher sterility grade from the dry chemical(AKDD). The package of the dry chemical had advantages to save working time and physical power for personnel.
