Abstract
Clinical evaluation was conducted for antithrombogenicity of three different HPMs (PAN: DX, PMMA: BK, and Cellulose: TF) with 6 patients. In SEM observation, more coagulations were observed with BK and TF than with DX. LDH, the index of blood cells adsorbed onto inner wall surface, was also higher with BK and TF. Blood residual ratio was lowest with DX. There was no significant difference among the three in the indices of thrombocyte activation (the number of platelets, β-TG and PF-4 values). In the indices of thrombosis (FPA and TAT values), the three showed a similar rising tendency during hemodialysis, but the tendency was most moderate with DX. As for D-dimer, the index of the secondory fibrinolysis, change during hemodialysis remained small with all of the three, without any reflections of the results of the SEM observation and the FPA and TAT values. Judging from the above results of evaluation, DX is considered most recommendable of the three HPMs.
