Abstract
Clinical effects of a new dialyzer, of which membrane pore size was enlarged from 70Å (FB-U) to 75Å (FB-F) were compared in 6 maintenance hemodialysis (HD) patients in crossover manner. There was no significant differennce in clearance (CL) of small molecular substances, such as urea, creatinine and uric acid. However, CL of β2M and myoglobin (MG) was significantly greater in FB-F than FB-U. Comparing to FB-U, significant increases in sieving coefficient (SC) of β2M were observed in FB-F at 30min and at the end of HD, but the SC of larger molecules than that of MG was not different between two dialyzers. Removal rates of both β2M and MG were significantly higher in FB-F than in FB-U. There were no significant changes in circulating leucocytes and platelets levels, C3a and C5a, and glanulocyte elastase between two membranes. From these results, it is concluded that FB-F is useful dialyzer in clinical use with higher elimination rates of low molecular weight proteins and excellent biocompatibility than FB-U.
