Abstract
The anticoagulative actvity of newly developed polyethylene glycol grafted cellulose membrane (AM-PC) was compared with that of conventional cuprammonium rayon membrane (AM-SD). The minimum requirement dose of heparin with AM-PC was significantly less than that of with AM-SD by 29±10%. The change in the levels of fibrinopeptaid A (FPA). Thrombin antithrombiniIr complex (TAT), β-thromboglobulin (β-TG) and platelet factor-4 (PF-4) during dialysis session was compared between two types of dialysis membrane under the minimum dosage of heparin. The levels of these parameters were increased significantly in both type of membrane after dialysis compared to those of pre-dialysis except PF-4. The change of these parameters was also compared as the ratio of outlet-values per inlet ones. It revealed the significant increase of β-TG was found at 5 minutes following initiation of dialysis and that of FPA, TAT and PF-4 were found at 240 minutes in AM-SD treated group. The increase of FPA, TAT and PF-4 was found at 240 minutes in AM-PC treated group, however, the differences in the rate of outlet per inlet were no significant between two types of membrane. The levels of 6-keto-prostaglandin F1α and 11-dehydro thromboxane B2 were determined under the condition as usual dose of heparin usage. The former showed significant increas in both membranes, however, the latter showed significant increase only in AM-SD. These results demonstrated that the dose of heparin could be reduced by use at AM-PC and suggested that this effect might be derived by less stimulative effect of AM-PC on thrombocyte.
