Abstract
Adequate conditions as to total dialysate volume (TDV) and tidal volume (TV) on 8 hr-TPD were studied in 4 patients with their peritoneal permeabilities (D/P creatinine at 4 hr) ranging from 0.62-0.91. TDV studied was 10, 16, 22 and 28L and TV, 0.5, 1 and 1.5L with 2L of initial infusion volume (IIV) using PAC-X-II cycler. Dialysis amount was expressed as total amount of urea removed/initial plasma urea levels (M/CB). Model calculation for M/CB was also conducted using single pool model. M/CB was not higher in TPD than in IPD when TDV was less than 16L. Significant improvement by 10-17% in M/CB was noticed on TPD using TDV of more than 22L. Maximum performance was obtained by 50% of IIV as a TV. Calculated M/CB was lower than measured one. In conclusion, TPD promises 10-17% higher urea removal performance than IPD when large TDV of more than 22L is used. Adequate TV is 50% of IIV. Eight hour, 22L-TPD provides weekly Kt/V of more than 1.75 in patients with average or high peritoneal permeability.
