Abstract
We synthesized Methyl-oligo-lactate (LTM) for absorbable bone wax. The hemostatic effectiveness and effect on osteogenesis of LTM were compared with those of conventional bone wax. Experimental animals used were 12 male white rabbits. On each side of the iliac bone, three adjacent cavities (φ3mm) were made with a drill. The two cavities on each side, were filled with LTM and bone wax respectively. The another cavity was remained untreated for control. Two animals were sacrificed at 1, 2, 4, 8, 12 and 16 weeks, respectively. In two rabbits LTM and bone wax were implanted in the lumber muscle, and sacrificed after one week. In the operation LTM showed sufficient hemostatic effect. On histological evaluation, tissue reaction of LTM was minimal, whereas that of control bone wax was sevier; sugessting harmlessness of LTM. However, the large part of LTM still remained even after 16 weeks. Therefore more rapid absorbable type of LTM are desirable for more effective bone wax.
