Abstract
This paper describes a novel photo-induced surface process technology providing a given biocompatibility on a given part of complex-shaped device. The material designed for this purpose was poly (N-acryloyloxysuccinimide) partially derivatized with N-(2-aminoethyl)-4-azidobenzamide. This bifunctional polymer was cast on a polymeric surface, followed by UV-irradiation. Then, the immersion into a buffer solution of a protein resulted in chemical fixation of protein. This was evidenced with the ESCA spectral study. Hydrophilic group-, cell adhesive peptide GRGDS- and fibronectin-fixed surfaces were prepared; the former were found to be free from cell adhesion, whereas the latter two were cell adhesive. Since the derivation of activated ester group on a polymer surface takes place only on an irradiated portion, a given biocompatible surface design at a given part of complex-shaped device was found to be feasible.
