Abstract
Safety and ease of use are key issues during whole body hyperthermia using extracorporeal circulation, also known as extracorporeal systemic hyperthermia (ESH). We used the technique of percutaneous puncture by 9F introducer for stabilizing blood flow and protecting against infection. We were able to accomplish safe control of blood temperature through proportional integration of ESH. Ten cases in which ESH was used were evaluated, and the following results were obtained. After about 40min from the start of ESH, pulmonary artery temperature exceeded 41°C, and it stabilized between 41.5° and 42°C after 90min. The maximum blood inflow temperature was set at 45°C which required a blood inflow rate of 0.8l/min to maintain. (The 9 F introducer allows for a maximum blood inflow rate of 1.4l/min.) At this temperature of 45°C, cardiac output and heart rate increased 2.6 times and 1.8 times, respectively. Forty-three patients with advanced primary non-small cell lung cancer also underwent ESH. Analgesic effect was observed in about 70% of the 25 cases with pain. The survival rate was not influenced by the stage of the disease, tumor effect, or the number of times treated with ESH. Among stage IV patients, the average survival period was 11 months.
