Effect of vevo-pulmonary extracorporeal membrane oxygenation with right ventricular assist

-Compare with it in veno-arterial ECMO-

Abstract

The purpose of this study is to compare the effects of veno-pulmonary extracorporeal membrane oxygenation (VP-ECMO) with veno-arterial ECMO (VA-ECMO) in 11 dogs. Under normal respiratory condition (G-C) and respiratory failure (G-RF), PaO₂ at carotid artery and SvO₂ at pulmonary artery were measured. Thereafter we established the bypass of VP-, and VA-ECMO (G-VP, G-VA) from the right atrium to pulmonary or femoral artery. PaO₂ in G-C, G-VP and G-VA were significantly higher than in G-RF. SvO₂ in G-VP was significantly higher than others. Left and right ventricle stroke work (L & RVSW) in each states were measured and not significant difference. Pulse pressure in G-VP kept about 80% of G-C, but in G-VA, Pulse pressure went off, and aortic flow became non-pulsatile flow. Then, the results suggested that the effects of oxygenation in VP-ECMO was as good as in VA-ECMO, and kept right and left ventricular function.