Abstract
IL-8 plays an important role in inflammation through its chemotactic and activating effects on neutrophils. To determine if IL-8 can be used as an index of biocompatibility of dialyzers, effects of hemodialysis (HD) using regenerated cellulose (RC) (TFα-1300H), PAN (PAN-13DX) or PMMA (BK-1.3P) on plasma IL-8 and peripheral blood mononuclear cell (PBMC) IL-8mRNA were studied. Plasma IL-8 levels significantly increased after HD using RC and PMMA, while they did not increase after HD using PAN. PBMC IL-8mRNA did not change after HD using PAN, but increased after HD using RC and PMMA. These results suggest that plasma. IL-8 level and PBMC IL-8 mRNA can be used as indices of biocompatibility of dialysis membranes.
