Abstract
Individualized therapy is capable of the quality control of dialysis treatments. In clinical situations, blood chemistries are taken only twice a month. Predicting blood concentrations from dialysate concentrations using mass balance equations is possible with real time evaluation of dialysis treatments at each hemodialysis. We measured the concentrations of urea, creatinine, phosphoric acid and uric acid in dialysate as well as in blood to confirm accuracy of the estimation during hemodialysis with high performance dialyzers for 8 patients. Estimation results for uric acid and phosphoric acid were not very accurate in treatments with high performance dialyzers compared with in those with conventional ones. Then an apparent distribution volume for each solute was determined for better estimation. The apparent distribution volume of uric acid was lower than that of urea, and that of phosphoric acid varied for each patient. These results demonstrate that the individualized therapy using a high performance dialyzer is feasible by collecting dialysate concentration data of the patients on hemodialysis.
