Abstract
In an attempt to remove the related substances in the plasma with fulminant hepatitis, in vitro study has been made to examine the effect of photo irradiation (at 376, 392 and 423nm) and adsorption with adsorbent. i. e. active carbon, anionic exchange resin or hydroxyapatite. The analysis with HPLC technique has clarified that the combination of photo-irradiation and adsorption was much more effective for the removal than the photo-irradiation or adsorption alone, as previously observed in our study for bilirubin removal. The light at wave length of 423nm was the most effective and caused less damage on plasma proteins. The effect of photo-irradiation may be explained by the detachment of albumin-bound substances. Thereby, the substances being converted to polar low molecular weight, then could easily be removed by adsorbents such as poly-HEMA coated active carbon.
