Abstract
We compared heparion-coated cardiopulmonary bypass circuit with non-coated circuit in terms of biocompatibility in 36 patients undergoing coronary bypass surgery. Two types of heparin-coated circuit were prepared; one was Carmeda MAXIMA with covalent heparin bonding (n=12) and the other was Duraflo II with ionic heparin bonding (n=12). Non-coated circuit was UNIVOX IC (n=12). We examined TAT, PIC, D-dimer, C3a, C4a, platelet count and ACT during bypass, and Respiratory Index after surgery. Concentration of C3a during the bypass was higher in the non-coated group than in the coated groups. Reduction of platelet count during bypass was significantly greater in the non-coated group than in the coated groups. There were no significant differences in the remaining parameters among the three groups. We concluded that heparin-coated cardiopulmonary bypass circuit improved biocompatibility by reducing complement activation and platelet consumption.
