Abstract
The liver ischemia is appeared at the begining of the CPB.And the lactate is metabolized at the liver.So we considered that the lactate administration at the CPB was unbeneficial to the liver. In order to assess the lactate effects of the liver, we compared the acetate Ringer's solution with the lactate Ringer's solution as the priming fluid of the CPB circuit. We used the arterial ketone body ratio (AKBR) for the redox state of the liver. The lactate's concentration increased in time dependent manner. But acetate was metabolized easily at the CPB.The arterial ketone boy ratio (AKBR)in acetate positive group was higher than that in lactate positive group.The base excess at CPB in the acetat positive group was higer than in the lactate positive group. So amount of the base was less in the acetate posiyive group than in the lactate positive group. .There was no difference in the systemic blood pressure and systemic vascular resistance between two groups.We conclude that the lactate loads more work on the liver at the CPB. So the acetate Ringer's solution is better priming fluid than the lactate Ringer's solution at the CPB.
