Abstract
MENOX AL 6000 is a new extracapillary blood flow type Polyolefin (PO) hollow fiber membrane oxygenator. We clinically evaluated MENOX AL 6000 comparing it with CAPIOX SX (Terumo). Thirteen patients who underwent elective coronary artery bypass grafting were divided into two groups, MENOX AL 6000 group (group M: 7 patients) and CAPIOX SX group (group C: 6 patients). In this study, blood samples were collected 5min before and after the initiation of cardiopulmonary bypass (CPB), then every 30min during CPB. The gas transfer capability was satisfactory, when it used MENOX AL 6000 for the patients with weights of 42.8-72kg. Corrected platelet count and plasma free hemoglobin were measured, and there were no significant differences between the two groups. However, the hemolysis index (plasma free hemoglobin/CPB time) was lower in group M than that in group C. Futhermore, as a result of a simple experiment (in vitro) which was originally devised to investigate the biocompatibility of PO hollow fiber in comparison with that of POlypropylene (PP) hollow fiber, the influence of PO hollow fiber on human blood (platelet count, TAT, FPB, C3a) was less than that of PP hollow fiber. In conclusion the membrane structure of the new oxygenator (MENOX AL 6000: made of PO hollow fiber) had a superior effect on human blood in comparison to that of the CAPIOX SX (made of PP hollow fiber).
