Abstract
The kinetics of serum enzyme were studied by comparing the serial changes during and after extracorporeal circulation (ECC) in 33 cases of open heart surgery. Serum amylase, isoenzyme of amylase, lipase, CPK, and isoenzyme of CPK were measured at eight points (pre-ECC, 30min after ECC, just after ECC, skin closure, arrival on ICU, 1st post operative day(1POD), 2POD, 3POD). Then the relationships between those and intraoperatve factors-age, operative procedures, aortic crossclamp time, ECC time, mean aortic pressure during ECC, ECC flow, the lowest rectal temperature, and cardiac index after operation-were estimated. The timing of peak of CPK level was different from that of CPK-MB/CPK. Also the timing of peak of amylase was different from those of Pamylase and lipase. There was no relationship between CPK levels and CPK-MB/CPK. Neither there was no relationship between serum amylase levels and P-amylase, lipase levels. There was no corelationship between CPK, serum amylase levels on 1POD, which showed abnormally high concentration, and the intra-operative factors, except the relationship between CPK and lowest temperature during ECC. Although serum CPK and amylase showed abnormally high concentration, specially after ECC, the relationship between those and ECC related factors could not be identified.
