SIGNIFICANT INFLUENCE OF FACTOR XIIIA ON PERIOPERATIVE BLEEDING AFTER CARDIOPULMONARY BYPASS

Abstract

Crosslinking of fibrin monomers by activated factor XIII is a final event in blood coagulation. We evaluated the serum level of XIIIa during cardopulmonary bypass (CPB) and their relationship with the extent of perioperative bleeding. And also coagulo-fibrinolytic molecular markers were analyzed Preoperative XIIIa levels ranged 62% to 123% (mean; 87%±20%) and the levels significantly fell down to 50%±13% at 10 minutes after the initiation of CPB and lower levels continued until the dscontinuation of CPB. Significant inverse coirelations were obsarved between preoperative leves of XIIIa and the extent of intraoperative bleeding, and there were the same associations between XIIIa levels during CPB andearly postoperative bleeding. In view of the above findings, low levels of factor XIIIa should be includedamong the list of risk factors for blood loss after cardiac surgery