Abstract
We tried to preparation of good biocompatible hydrogel, and studied to the biomedical applications. Collagen solution were incubated with Copper (II) ion (0.1mM) and ascorbate (0.1mM) in neutral buffer (pH7.4) at 37°C for 4hr, and made translucent and viscoelastic hydrogel. The hydrogel was capable of absorbing water of 20 to 200 times of its deadweight and had hemostatic effect. It was cleared that hydrogel showed a good tissue-compatibility and biodegradability after implatation in rats. Therefore it is concluded that the hydrogel can be used in biomedical applications such as drug delivery systems, hemostat, and wound dressings.
