Abstract
We studied the clinical usefulness of heparin-coated cardiopulmonary bypass circuits (Duraflo II, H group) compared with non-coated circuit (N group) in patients with CABG. Alveolar-arterial oxygen pressure gradients (A-aDO2), respiratory index (RI) and intrapulmonary shunt (Qs/Qt) were compared. There was no significant difference in the A-aDO2 or RI. However, immediately after operation, the Qs/Qt in the N group increased significantly more than that in the H group (p<0.05). Six hours after operation, the difference between both groups in the Qs/Qt disappeared in the intensive care unit. There was no difference in the cardiac performance, liver function, renal function or the time of intubation and ICU stay between these groups. These results indicate that the heparin-coated circuits may be beneficial for these patients with preoperative lung dysfunction.
