Abstract
In the present study we investigated the changes in contact factors in cardiopulmonary bypass (CPB) using hemofiltration (HF) for priming blood. Red cell concentrates containing MAP (RC-MAP) and albumin solution were used for the pnming. Blood samples were collected from RC-MAP, priming solution before and after HF, hemofiltrate and patient before CPB, and 60 minutes after CPB and at the end of CPB. In 10 cases, high molecular weight kininogen (HMWK), prekallikrein (PK), factor XII (F XII) and bradykinin (BK) levels were examined in each sample. Through hemodilution and contact with the CPB circuit, HMWK, PK and F XII were consumed and a large quantity of BK was generated, but BK was hemofiltrated well. At the beginning of CPB, HMWK, PK and F XII were significantly decreased, since then they were not significantly changed. BK was not significantly changed during CPB. Because BK increases vasodilatation and capillary permeability, HF is useful to prevent a drop in blood pressure at the beginning of CPB and for the reduction of postoperative edema, especially in neonates and infants.
