Abstract
We evaluated changes in platelet function during cardiopulmonary bypass (CPB) and effects of retransfusion of autologous platelets collected before CPB, by percent shortening of activated coagulation time (clot ratio) resulting from addition of platelet activating factor (PAF) using hemoSTATUS. Changes during CPB were evaluated in nine adult patients who underwent heart surgery under mild hypothermia. Patients' age was 61±11 years and CPB time was 145±22 minutes. Clot ratio to 150nM of PAF significantly decreased to 81±12% five minutes after the onset of CPB and subsequently recovered 30 minutes after the onset of CPB (p<0.05). Effects of autologous platelet retransfusion were evaluated in 10 adult patients. Two aortic operations under profound hypothermia were included. Patients' age was 62±14 years and CPB time was 190±90 minutes. Collection of 8.2±3.0 units of platelets resulted in a significant decrease in platelet count (from 18.5±3.3 to 12.3±3.9, p<0.01) but no change in the clot ratio. Retransfusion of the autologous platelets resulted in a significant recovery of the clot ratio (from 90±23% to 110±20%, p<0.01). Results of the hemoSTATUS platelet function test suggest the beneficial effects of retransfusion of autologous platelets.
