Abstract
We compared the effects of pore size in PMMA filter on mediator elimination during continuous hemodiafiltration (CHDF). Thirteen patients with multiple organ dysfunction syndrom treated with CHDF were the subjects of this study. Seven patients were studied for large size pore PMMA filter (100Å), and six patients for ordinary one (70Å). The concentration of granulocyte elastase, myeloperoxytase, IL-6 and IL-1β were measured before and after the filter and in ultradiafiltrate. Each clearance of mediators were calculated. There was no difference in clearance in granulocyte elastase between large size pore PMMA filter and ordinary on (large size pore: -12.1±27.3ml/min, ordinary size pore: -1.9±17.2ml/min). Myeloperoxytase was not eliminated in ultradiafiltrate. The clearance of IL-6 was not different between both filters. The concentration of IL-1 was undetectable in 50% of the patients. We could not find any difference in the mediator elimination between large size pore PMMA filter and ordinary one in this study.
