Abstract
This study describes the development of two novel visible light-induced surface modification methods providing durable layering of hydrophilic polymers on the material of fabricated devices, which are based on the photochemistry of camphorquinone. One is surface graft copolymerization, which occurred via irradiation of polyurethane and poly (vinyl chloride) films impregnated with 1, 12-dodecane end-capped with camphorquinone through the film in an aqueous N, N-dimethylacrylamide (DMAAm) solution. The other is surface hydrogelation, which occurred via coating of the photoreactive polymer, which was radical copolymer of DMAAm and camphorquinonederivatized styrene, on a poly (ethylene terephthalate) film and subsequent irradiation. These were confirmed by X-ray photoelectron spectroscopic analyses and water contact angle measurements. Confocal laser fluorescence microscopic observations after staining with a fluorescence dye showed that thickness of the produced polymer layer increased with irradiation time in graft copolymerization. The treated surfaces extensively prevented blood coagulation. These methods were applied for conferring potent biocompatibility to the inner surface of a fabricated artificial heart.
