Abstract
Fluorocarbon particles are said to be chemically inert. However, detailed analysis of the influence of intravascular fluorocarbon upon the internal organs of the animals was not established.
Histological examinations were performed after intravenous injection of fluorocarbon into the Wister-strain rats.
Fluorocarbon disappearance curve from blood showed almost exponential. Its T-1/2 was 30 minutes. Increases in splenic, hepatic, and pulmonary weight and their fluorocarbon content did not correlate, which meant the weight gain was not due to simple trapping. Granulomas were found in the liver and spleen. In the lungs, interstitial round cell infiltration and thrombosis were marked.
In a long period of time, fluorocarbon deposited in the lungs was a substantial percentage of the injected amount.
Leukocytosis with neutrophilia, in correspondence with the shift in the bone marrow, was seen. Platelet count was decreased. Reticular cells and histiobasophils were increased in the bone marrow.
From these experiments, intravascular fluorocarbon activates the Reticuloendothelial system, making granulomas and mobilizing the reticular cells. Fluorocarbon is accepted as a foreign body in the experimental animals.
It is strongly suggested that fluorocarbon is not biologically safe and causes certain disturances to the animals.
