Abstract
Copolymer of some α-amino acids show promise as a new class of materials suitable not only for the fabrication of implantable prostheses but also for the simulater of the collagenlike biomaterials constructed in the vein, pericardium, peritoneum and so on. The glutamic acid ester-leucine copolymer system is an example where the mechanical properties can be varied over a wide range. The relative thromboresistancy of the cast films prepared from the ratios of the benzyl or methyl ester of glutamic acids with leucine, listed below, was measured with a modified kinetic clotting protocal developed for this purpose. The result show that copolymers with high ratios of the γ-benzyl glutamate have a thromboresistancy superior to Silatic (MDX-4514 Dow Corning). As the ratio of the γ-benzyl glutamate decreased or replaced by γ-methyl glutamate, the thromboresistancy decreased and copolymers of D and E lie between that of glass and silastic.
A) Poly-γ-Benzyl-L-Glutamate.
B) Copoly (γ-Benzyl-L-Glu, L-Leu. 50: 50).
C) Coopoly (γ-Benzyl-L-Glu, L-Leu. 17: 83).
D) Copoly (γ-Methyl-L-Glu, L-Leu. 46: 54).
E) Copoly(γ-Benzyl-L-Glu, γ-Methyl-D-Glu. 19: 81).
