Abstract
The effects of intraaortic balloon pumping (IABP) on the severity of myocardial ischemic injury, the collateral flow and the myocardial metabolism were studied in 20 dogs following acute LAD coronary artery occlusion.
Following one hour of the observation of the ischemic changes in myocardium, IABP was initiated for one hour using our designed assist device.
The significant diastolic augmentation of central aortic pressure and the reduction of left ventricular impedance were observed during IABP.
Serial epicardial electrograms revealed that IABP significantly reduced the magnitude and extent of myocardial ischemic injury after experimental LAD occulusion.
Retrograde flow from the ischemic LAD bed significantly increased by 42.5±4.30% during IABP (P<0.05).
During one hour of IABP, the oxygen extraction rate in the ischemic area was reduced and the lactate extraction rate also significantly improved from-34.8±6.10% to-14.8±4.20% (P<0.05).
However, these beneficial effects by IABP were reversed immediately after pump off and therefore to expect the sufficient “after effects” IABP must be continued for longer period until natural development of coronary collaterals is completed.
In addition, 4 cases of our clinical trials were presented and the marked improvement in hemodynamics during IABP was observed in cardiogenic shock patient following massive myocardial infarction.
