Abstract
Antithrombogenic enzymes Urokinase and Streptkinase were immobilized to the graft copolymer of atelo collagen and silicone. The vascular grafts with 5-7mm diameter were inserted in the aorta of 11 dogs. All grafts checked until 31 days were still open. The obstruction by the organized thrombus was found at 5 of 7 grafts investigated after 65 days. The patency of a graft was observed by the angiography at 118th day. By the SEM studies, the adhesion of amorphous cells on the inner surface and a little of fibrin network at the proximal end were found after 30min. After 1 hour, the thin membrane covered the inner surface. The enzyme coated vascular graft can make the thrombus thinner in the canal at the early period of the implantation.
