In vitro and Clinical Evaluation on Creatinine Transport Dynamics in Blood

Abstract

Although creatinine (CR) has been long used as an indicator for the measurement of renal function and dialyzer performance, its dynamic behavior in blood has not been thoroughly clarified. For establishing a method to accurately determine CR dialysance (D), distribution of CR as well as urea (U) between red blood cell (RBC) and plasma (P) has been studied in vitro and clinically. In contrast to U which diffuses almost instantaneously through RBC membrane, CR is proven to traverse so slowly that an equilibrium can not be reached within 9 hours. Prompt P separation and D calculation based on P concentration are necessary for the accurate detericination of CR related parameters.