Abstract
XAD-4 resin is an uncoated and uncharged acrorenticular, styrene-diviriylbenzene coolymer with particular adsorbability for ipid-soluble and protein-bound substances, eing one of the most promising among various adsorbents for hepatic support. Depletion of the platelet and WBC is, however, one of the ritical problems for its clinical application.
To improve the blood compatibility, the coating of the resin by various materials, such. as Diacetylchitin, Poly-γ-benzyl-L-glutamic acid (PBLG), Cellulose acetate (CA) and Lysine ave been adopted and evaluated.
In vitro adsorption studies for ICG and entobarbital, followed by ex vivo blood comatibility study indicated Diacetylchitin, PB G and CA were promising in this order. In _vitro studies revealed Diacetylchitin effective o improve the blood compatibility, both for BC and platelet, PBLG was effective only for BC, while CA was for neither of them.
Based on these studies, Diacetylchitin coating of the XAD-4 resin is believed to be eady for clinical use.
In addition, the systematic evaluation or coating materials descrived here is recomended, because of its simplicity, reproducibility and requirement for small quantity of iven material for the study.
