Abstract
Recently, septic acute renal failure (ARF) patients show the tendency to increase. Since the mortality rate of this septic ARF remains high, the development of more effective treatment is urgent and important. The septic ARF frequently complicates other important organ failures such as pulmonary and hepatic one, and can be considered as a part of the multiple organ failure (MOF).
The impairment of reticuloendothelial system (RES) function seems to play a key role for the development of MOF. Therefore, the treatment for the depressed RES can be effective for septic ARF as well as for MOF. For this purpose, we have applied the direct hemoperfusion (DHP) with conventional hemodialysis expecting that DHP would work as an artificial RES and that DHP would improve RES function by detoxifying the toxic factors depressing the RES. We have also given some agents improving RES function.
Using these new regimen, we could get the significantly better survival rate of 77.8% (7/9) compared to that with the conventional treatment. This result indicates that DHP as an artificial RES is effective for the treatment of septic ARF.
