2022 Volume 2022 Article ID: 220410
Scanning probe microscopy has been used to characterize structures and electronic properties of surfaces as well as to construct nanostructures via atom-by atom manipulation. Recent advances in tip-functionalized scanning probe microscopy allow us to measure the inner structures of molecules. This bond-resolved imaging technique is of particular importance in the investigation of precursors and products during on-surface reactions. In this article, tip-induced structural isomerization and additional reactions will be discussed.