Comparison of the efficiency and safety of oxygen supply methods in home oxygen therapy: oxygen concentrators vs. liquid oxygen

Abstract

Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide and has a high prevalence in Japan. The Ministry of Health, Labour and Welfare has set a goal to reduce COPD-related mortality under the “Healthy Japan 21 (Phase 3)” initiative. In the home healthcare of patients with severe COPD, the combined use of home mechanical ventilation (HMV) and home oxygen therapy (HOT) is common; however, a decline in FiO₂ remains a challenge. This study compared liquid oxygen (LO) and oxygen concentrators (OC), demonstrating that LO can maintain higher FiO₂ levels. In the comparison of oxygen delivery devices, LEGEND AIR showed superior performance compared to other ventilatory devices.