2019 Volume 10 Issue 2 Pages 139-142
Endotoxin adsorption therapy is used to treat severe sepsis. In recent years, adsorption columns have been developed to treat neonatal sepsis, of which polymyxin B-immobilized fiber (PMX) columns can even be used for low-birth-weight neonates. The infant was born at 36 weeks gestation, weighing 2504 g. Within 4 hours after birth, respiratory insufficiency due to Group B Streptococcus infection was observed. Blood pressure was stabilized after antibiotic and nitric oxide (NO) treatments; however, procalcitonin concentrations were high and symptoms of sepsis were observed. Blood purification therapy including PMX, was administered on the third day after birth. Improvement in respiration and circulation was observed after the introduction of blood purification therapy. As a result, the administration of NO and catecholamine preparations was gradually reduced, and blood purification therapy was discontinued after 53 hours. The infant was discharged about 2 months later. The development of low-dose PMX-01R has made it possible to implement the safe treatment of sepsis in newborns.
