Predictive factors of circuit coagulation during continuous renal replacement therapy using recombinant human soluble thrombomodulin

Abstract

We investigated the predictive factors of circuit coagulation during continuous renal replacement therapy (CRRT) using recombinant human soluble thrombomodulin (rTM). 43 patients who underwent CRRT with rTM (rTM-CRRT) at our hospital between May 2015 and May 2019 were divided into two groups. The coagulation group (n=10) included patients who required circuit replacement owing to early coagulation and non-coagulation group (n=33) included patients who underwent periodic circuit replacement. The examination items were APACHEⅡ score, SOFA score before CRRT was started, DIC score, blood test (blood cell count, serum chemistry, and coagulation system), and activated clotting time(ACT) on the blood effusion side at the start of CRRT. As a result of multivariant analysis, a significant difference was observed in soluble fibrin(SF) of the coagulation system only. Therefore, SF value before the initiation of CRRT may be possibly predict the occurrence of circuit coagulation during rTM-CRRT.