2023 Volume 13 Issue 2 Pages 114-115
In continuous renal replacement therapy (CRRT), hemofilter clotting is one of the frequent troubles. Polysulfone (PS) membranes with polyvinylpyrrolidone (PVP) as a hydrophilic agent are widely used as hemofilters for CRRT. Recently, Toray Medical Co., Ltd. developed a new PS membrane hemofilter that uses NV polymer as a hydrophilic agent. They claim that the NV polymer has better hydrophilic properties than the PVP polymer. In this study, we retrospectively analyzed whether the difference of these two hydrophilic agents (PVP and NV polymer) will affect hemofilter lifetime. The subjects were 20 individuals who met all of the following conditions: they are maintenance hemodialysis patients who underwent CRRT after cardiac surgery, the CRRT mode was via continuous hemofiltration, and the anticoagulant used was nafamostat mesilate. We compared the achievement ratio of the hemofilter lifetime for 48 hours for the two groups (PS membrane with NV polymer (NV group; 11 cases) vs PS membrane with PVP polymer (PVP group; 9 cases)). Results showed that the hemofilter lifetime achievement rate for 48 hours was significantly higher in the NV group than in the PVP group (45.4% vs 0%, p = 0.038). In the context of CRRT for maintenance hemodialysis patients after cardiac surgery, the antithrombotic performance of the PS hemofilter coated with NV polymer is better than that coated with PVP polymer.
