Evaluation of circuit coagulation during AN69ST-CHF using ACH-Σ and Prismaflex

Abstract

[Introduction] In our institution, continuous hemofiltration (CHF) with AN69ST hemofilter (AN69ST-CHF) is performed using ACH-Σ and Prismaflex console. In this study, we retrospectively investigated the occurrence of circuit coagulation during AN69ST-CHF using ACH-Σ (Σgroup) and Prismaflex (P group). [Methods]Patients who underwent AN69ST-CHF at a total nafamostat mesylate dose rate of 30 mg/h (dispensed dose method in group Σ and pre-filtered dose method in group P) were selected. We defined goal attainment as the ability to perform CHF for more than 22 h with one filter and compared the target attainment rates and coagulation sites for each CHF procedure. [Results] There was no difference in the rate of CHF goal attainment between the two groups (group Σ: 72.7% (16/22) vs. group P: 77.3% (17/22) , p = 0.73) , and there was significantly lesser V-chamber coagulation in group P than in group Σ (group Σ: 5/6 vs. group P: 1/5, p＜0.05) . [Conclusion] When AN69ST-CHF was performed, there was no difference in the rate of goal attainment between the two groups. The incidence of V-chamber coagulation was significantly lower in the P group.