2023 Volume 14 Issue 1 Pages 37-40
Continuous hemodiafiltration（CHDF）using a cytokine-adsorbing polymethyl methacrylate (PMMA) membrane has been reported to be effective in controlling hypercytokinemia after infection. In this study, we evaluated the efficacy of hemodiafiltration/hemodialysis using a PMMA membrane（PMMA-HDF/HD）. From January 2021 to March 2022, PMMA-HDF/HD was performed in 10 patients with sepsis and high interleukin-6（IL-6）levels (six men/four women, mean age 73.6 ± 14.3 years). IL-6 levels and white blood cell counts significantly decreased after performing PMMA-HDF/HD, and all the patients survived. PMMA-HDF/HD can be used for acute blood purification from the early infection stage because it can provide a treatment regimen close to CHDF in the intensive care unit even in the dialysis room by changing the dialysis conditions, and can therefore, be considered to contribute to the prevention of disease progression.
