Body-friendly blood purification therapy for sepsis

Abstract

A dysregulated host response to infection causes sepsis-induced organ damage. Various mediators are associated with pathogenesis, and continuous hemofiltration is used to remove high molecular weight substances, such as cytokines and DAMPs, in sepsis-associated acute kidney injury. There have been various reports on the conditions of blood purification therapy (BPT) for sepsis, but no unified view has been reached. In this study, we present and discuss the BPT in our hospital from the viewpoints of (1) blood purification dose, (2) biocompatibility, and (3) hemofilter lifetime. From the viewpoint of “regulating” the general condition that may lead to organ damage or failure, a “body-friendly” blood purification system that considers biocompatibility and hemofilter lifetime should be established.