2024 Volume 15 Issue 1 Pages 42-47
Objective: We analyzed only the cases experienced at our facility from the multicenter trial data evaluating the safety and efficacy of granulocyte adsorption columns in septic patients. Methods: The study included patients diagnosed as sepsis and with an APACHE Ⅱ score ranging from 17-34．A total of five G-1 direct perfusion (G-1-DHP) procedures were performed within 3 days of intensive care unit (ICU) admission. The primary endpoint was the change in SOFA score from ICU admission to 7 days, and the safety endpoints were adverse events and mortality at 28 days. Results: The study included 20 patients, with a median age of 72.5 years (IQR 68.3-75.8) and a median APACHE Ⅱ score of 23.5 (IQR 20.0-28.8). G-1-DHP demonstrated effective adsorptive removal of granulocytes. The SOFA score significantly decreased from a median of 8 to 3 after 7 days (p＜0.01). No adverse events related to G-1 treatment were observed, and all patients survived for 28 days. Conclusion: G-1-DHP is a promising novel treatment for sepsis that may help prevent the progression of organ damage.
