Blood retention factors of vertical inflow venous chamber in CKRT

Abstract

In continuous kidney replacement therapy (CKRT), the venous chamber (VC) is a site where blood coagulation is common, and one of the factors is blood retention. In this study, we investigated the effect of a vertical inflow VC on blood retention, focusing on three retention factors: blood flow rate (QB), supplemental fluid flow rate (QS), and liquid layer separation. VC was used JCH-55X2-CHDF-2 (JMS). The evaluation items were classified as QB (80, 150 mL/min), QS (0, 0.3, 0.6 L/hr), and the presence of liquid layer separation. These were examined in a total of 12 ways. The QB had a strong stirring effect in the middle and bottom of the VC, and high QB reduced retention more than low QB; the use of QS reduced retention in the top of the VC through dilution and the effect of a drop impact on the VC liquid surface. Liquid layer separation reduced the drop impact on the VC liquid surface, but positively affected the turning force of blood flow. The combination of high QB, use of QS, and liquid layer separation reduces retention throughout the vertical inflow VC.