2024 Volume 15 Issue 2 Pages 133-137
In acute blood purification therapy, it is crucial to use a hemofilter that shows low blood cell adhesion in order to prevent hemofilter clotting, which can have a significant impact on patients, staff, and medical resources. The aim of the present study was to investigate the basic performance of two hemofilters made of different materials using an in vitro experimental model. We utilized fresh porcine blood obtained from a single animal for the experiments, and compared the blood cell adhesion characteristics between HemofeelⓇ SNV（SNV）and UT FilterⓇ（UT）using in vitro experimental model. The filtrate was returned to the circulating blood. The experiment was conducted for 24 hours with a blood flow rate of 100 mL/min and filtrate flow rate of 10 mL/min. The heparin addition rate was adjusted to maintain an activated clotting time of 200-300 s during the experiment. The results revealed that UT showed a higher change of the transmembrane pressure（TMP）during the 24-hour hemofiltration and a greater amount of red blood cells and total blood cells in residual blood clotting adhering to the membrane, as compared to SNV. Thus, SNV showed a lower TMP and lower blood cell adhesion than UT.
