2025 Volume 16 Issue 1 Pages 2-8
It has been proposed under the concept of “cytokine theory of disease” that many pathological conditions, especially acute pathological conditions such as severe sepsis, are developed by cytokine storm where blood interleukin-6 (IL-6) levels exceed 1,000 pg/mL. IL-6 has been chosen as a biomarker of cytokine storm because it is most easily measurable cytokine among many kinds of cytokines in clinical settings. As for the countermeasures against cytokine storm we apply continuous hemodiafiltration with cytokine-adsorbing hemofilter (CAH-CHDF). CAH-CHDF can effectively and continuously remove many kinds of cytokines from blood stream of a patient and thus CAH-CHDF can decrease the blood levels of cytokines. This decrease of the blood cytokine levels results in the improvement of various organ function and in the improvement of survival. Thus, we conclude that cytokine storm should be considered as a main feature of acute pathological conditions and that CAH-CHDF is a very effective countermeasures against cytokine storm.
