2025 Volume 16 Issue 1 Pages 40-43
Acute exacerbation of interstitial pneumonia (AE-IP) is associated with a high mortality rate. Recently, the effectiveness of endotoxin adsorption therapy (polymyxin B-immobilized fiber column direct hemoperfusion) for AE-IP has been reported. The patient was a man in his 60s with underlying IP who presented with dyspnea and was diagnosed with respiratory failure due to AE-IP, requiring mechanical ventilation. Arterial blood gas analysis after endotracheal intubation revealed hypercapnia and transthoracic echocardiography revealed right-sided heart failure. We administered combined hemodiafiltration (HDF) and PMX-DHP therapy and management using cardiovascular agents. After blood purification therapy, hypercapnia improved and right heart function recovered. We actively implemented prone positioning therapy and early respiratory rehabilitation, successfully weaned the patient from mechanical ventilation, and helped them survive during the acute phase.
